A scoring system for quantifying disease burden was developed, taking account of tumor number, size, spread, and secondary effects on the eye. Methods: A coding system was devised to describe each tumor according to affected eye, meridian, anteroposterior location, activity, growth pattern, type of seed, and treatment. The aims of this study were to develop methods for documenting individual tumors and to score disease burden over time. Background/Aims: Current retinoblastoma staging systems do not adequately describe the disease, especially in eyes with multiple tumors.
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